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As the United States begins the formal process of untangling itself from these 66 organizations, the long-term effects remain to be seen. The administration has left the door slightly ajar for “selective re-engagement” should a specific strategic interest arise, but the overall trajectory is clear. This policy represents a historic gamble: the belief that the United States is strong enough to thrive in an interconnected world by acting alone. Whether this move leads to a more prosperous and sovereign America, or results in a period of global instability and diminished American influence, is a question that will define the coming decade of international relations. For now, the world is watching as the United States recalibrates its identity and its role on the global stage, moving away from the center of the multilateral world it helped create.